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    Stress, Depression, Inflammation, and Psychoneuroimmunology (English Edition)

    Por Pharm Tao

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    Psychological stress has been associated with higher levels of inflammation and the risks of many physical disorders including heart diseases. Inflammatory processes are the common complications of a wide range of diseases including diabetes and cancer.

    The emerging field of psychoneuroimmunology (PNI) focuses on the interactions among the immune system, the central nervous system (CNS), and behavior. An integrative approach is needed to combine immunology and neuroscience to have a holistic view of the associations among stress, inflammation, and chronic diseases.

    Depression has been associated with higher levels of inflammatory activities. Inflammation can be enhanced by stress and depression, such as in the condition of troubled relationships. It is necessary to examine the influences of depression on the morbidity and mortality in chronic disorders including cardiovascular diseases, cancer, obesity, diabetes, asthma, and arthritis.

    Sleep disturbance has a significant role in the development of both mental and physical diseases, including depression, infectious diseases, cardiovascular diseases, and cancer. The interactions between sleep and health in both psychological and physical aspects may have significant effects on inflammation. Studies on the psychosocial and neurobiological processes underlying the pathophysiology of insomnia may contribute to the integrative interventions of various disorders.

    PNI studies have indicated that bipolar disorder (BD) is associated with a chronic pro-inflammatory condition. Autism spectrum disorders (ASD) are related to the malfunctions of multiple biological pathways. In the pathophysiology of schizophrenia, activated peripheral and central inflammatory responses play critical roles. Environmental and genetic factors may be involved in these inflammatory processes and the progression of schizophrenia.

    Impulsive behaviors are the important features of the disorders including borderline personality disorder (BPD) and attention-deficit/hyperactivity disorder (ADHD). In addition to conventional therapies, immunotherapy may provide promising interventions for the problems such as nicotine addiction and stimulant use disorders.

    Both genetic and environmental factors can influence human personality. Gene-environment interactions may affect neural processing and play a critical role in individual differences in behaviors and disease susceptibility. The identification of these factors can help with the development of strategies for more targeted care in personalized medicine.

    The interactions between genetic variabilities and environmental stressors may result in higher levels of inflammatory biomarkers among genetically susceptible adults. The studies of the associations among life stress, depression, and inflammation may be useful for the discovery and development of better therapeutic strategies.
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